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Image of SAMe 400 mg (S-Adenosyl-Methionine)
  • SAMe 400 mg (S-Adenosyl-Methionine)

    Product UPC#

    Item# LEF1933

  • Retail Price: $36.00
  • Our Price: $24.30
  • Your Savings: 32% off

  • Quantity
SAMe (S-Adenosyl-Methionine) 400 mg
SAMe helps maintain stable mood and joint function without side effects. In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. Largely known for its effects on optimal mood, SAMe has also shown benefits for the liver, brain, and joints.

Benefits at a glance:

  • Helps maintain stable mood
  • Helps maintain liver health
  • Helps maintain healthy joint function

    Life Extension® first introduced SAMe (S-Adenosyl-Methionine) in 1997, and researchers continue to discover impressive benefits of this versatile nutrient.

    SAMe is an amino acid derivative normally synthesized in the body that may become depleted with sickness or age. Supplementing with SAMe plus folate, trimethylglycine (TMG or betaine), vitamins B6 and B12 appears to be an effective way to overcome this deficiency.

    SAMe is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, and catecholamines and other neurotransmitters. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin. SAMe facilitates glutathione usage, which improves the body's antioxidant defense. It also helps maintain acetylcholine levels which are necessary for cognitive function.

    SAMe is used by the body in three important pathways:

  • Methylation (contributing methyl groups to activate certain molecules)
  • The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)
  • Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals) In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Its findings show the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects. Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.
  • SAMe has multimodal mechanisms of action that are used throughout the body and especially in the liver. In order to perform its detoxification role, the liver continually performs large numbers of complex enzymatic reactions. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of glutathione, a critical antioxidant. When liver function is compromised, glutathione is depleted, which leads to free radical damage. In addition, SAMe acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.

    • Directions

      Directions: Take one (1) tablet two to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid.

    • Ingredients

      Ingredients: 1 enteric coated tablet supplies:
      S-Adenosyl-Methionine 400 mg
      Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, stearic acid, silica, glyceryl triacetate, sodium starch glycolate, crosarmellose sodium, titanium dioxide, yellow ochre.

      Warning: SAMe should not be taken by those diagnosed with bipolar disorder. KEEP OUT OF REACH OF CHILDREN DO NOT EXCEED RECOMMENDED DOSE Do not purchase if outer seal is broken or damaged. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

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